TY - JOUR
AU1 - Giang, Le Nhat Thuy
AU2 - Nga, Nguyen Thi
AU3 - Van, Dinh Thuy
AU4 - Anh, Dang Thi Tuyet
AU5 - Phuong, Hoang Thi
AU6 - Thanh, Nguyen Ha
AU7 - Anh, Le Thi Tu
AU8 - Trung, Vu Quoc
AU9 - Van Tuyen, Nguyen
AU1 - Van Kiem, Phan
AB - A series of 4-anilinoquinazoline–triazole–AZT hybrids were designed and synthesized as anticancer agents. Their cytotoxic potential has been evaluated by means of a micro-dilution assay against three human cancer cell lines (KB, epidermoid carcinoma; HepG2, hepatoma carcinoma; SK-Lu-1, non-small lung cancer). The biological results revealed that compounds 4b and 6d showed good anticancer activities against KB, HepG2, and Lu cell lines (IC50 values ranging from 9 μM to 100 μM). Especially, compounds 4b and 6d exhibited up to 3-fold more potent than reference drugs erlotinib hydrochloride and AZT in term of anti-lung cancer activity.
TI - Design, Synthesis and Cytotoxic Evaluation of 4-Anilinoquinazoline– triazole–AZT Hybrids as Anticancer Agents
JF - Natural Product Communications
DO - 10.1177/1934578X1801301215
DA - 2018-12-01
UR - https://www.deepdyve.com/lp/sage/design-synthesis-and-cytotoxic-evaluation-of-4-anilinoquinazoline-k0ZkO5ud7h
SP - 1934578X1801301
VL - 13
IS - 12
DP - DeepDyve
ER -