TY - JOUR
AU - Younkin, S G
AB - The approximately 120-kilodalton amyloid beta protein precursor (beta APP) is processed into a complex set of 8- to 12-kilodalton carboxyl-terminal derivatives that includes potentially amyloidogenic forms with the approximately 4-kilodalton amyloid beta protein (beta AP) at or near their amino terminus. In order to determine if these derivatives are processed in a secretory pathway or by the endosomal-lysosomal system, (i) deletion mutants that produce the normal set of carboxyl-terminal derivatives and shortened secreted derivatives were analyzed and (ii) the effect of inhibitors of endosomal-lysosomal processing was examined. In the secretory pathway, cleavage of the beta APP occurs at a single site within the beta AP to generate one secreted derivative and one nonamyloidogenic carboxyl-terminal fragment, whereas, in the endosomal-lysosomal system, a complex set of carboxyl-terminal derivatives is produced that includes the potentially amyloidogenic forms.
TI - Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
JO - Science (New York, N.Y.)
DO - 10.1126/science.1738847
DA - 1992-03-19
UR - https://www.deepdyve.com/lp/pubmed/processing-of-the-amyloid-protein-precursor-to-potentially-k0KFTYMhrO
SP - 728
EP - 730
VL - 255
IS - 5045
DP - DeepDyve
ER -