TY - JOUR
AU1 - Salvati, Brianne
AU2 - Santagapita, Patricio
AU3 - Perullini, Mercedes
AB - Alginate-based hydrogels are being produced worldwide for a broad spectrum of biotechnological applications, from biomedicine to agriculture. In particular, nanosized alginate-based particles have emerged as promising platforms mainly for drug delivery applications. In view of their size they can be delivered in a minimally invasive manner, and being structurally similar to the extracellular matrix of many tissues they freely diffuse to the target cells. The mild conditions of the sol-gel process are intrinsically adapted for the development of applications that require the inclusion of bio-entities during synthesis. However, one of the limitations of these systems is the fast gelling rate that hinders an adequate inclusion of bioactive molecules in nano-size hydrogel systems. In this work, we present a literature review and explore the classical theoretical work on sol-gel chemistry of alginates to discuss the range of conditions in which alginate sol-gel processes can be controlled, aiming at nanogel preparation.[graphic not available: see fulltext]
TI - Exploring the conditions to generate alginate nanogels
JF - Journal of Sol-Gel Science and Technology
DO - 10.1007/s10971-021-05631-w
DA - 2022-04-01
UR - https://www.deepdyve.com/lp/springer-journals/exploring-the-conditions-to-generate-alginate-nanogels-jwUzdQaoxg
SP - 142
EP - 150
VL - 102
IS - 1
DP - DeepDyve
ER -