TY - JOUR
AU1 - Liao, James K.
AB - Review in depth 247 Hironori Nakagami and James K. Liao Cardiac hypertrophy is a physiological adaptive response cardiac hypertrophy. Coron Artery Dis 15:247–250 2004 by the heart to pressure overload. However, after pro- Lippincott Williams & Wilkins. longed periods, this initial adaptive response becomes maladaptive, leading to increased mortality and morbidity Coronary Artery Disease 2004, 15:247–250 from heart failure. Recently, 3-hydroxyl-3-methylglutaryl Keywords: cardiac hypertrophy, 3-hydroxyl-3-methylglutaryl coenzyme A coenzyme A (HMG-CoA) reductase inhibitors, or statins, reductase inhibitors, statins, antioxidants, small GTP-binding proteins have been shown to inhibit cardiac hypertrophy by cholesterol-independent mechanisms. Statins block the Vascular Medicine Research, Brigham and Women’s Hospital and Harvard Medical School, Cambridge, Massachusetts, USA. isoprenylation and activation of members of the Rho guanosine triphosphatase (GTPase) family, such as RhoA and Rac1. Since Rac1 is a requisite component of reduced Conflicts of interest: none nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which is a major source of reactive oxygen Correspondence and requests for reprints to: James K. Liao, MD, Vascular Medicine Research Unit, Brigham and Women’s Hospital, 65 Landsdowne species (ROS) in cardiovascular cells, the ability of statins Street, Room 275, Cambridge, MA 02139, USA. to inhibit Rac1-mediated oxidative stress makes an Tel: + 1 617 768 
TI - Statins and myocardial hypertrophy
JF - Coronary Artery Disease
DO - 10.1097/01.mca.0000130229.18685.b9
DA - 2004-08-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/statins-and-myocardial-hypertrophy-jtwLPC7ZYl
SP - 247
EP - 250
VL - 15
IS - 5
DP - DeepDyve
ER -