TY - JOUR
AU - Zawadzki, Zbigniew A.
AB - Abstract A 78-year-old woman, who had received steroid therapy for four years, had strikingly prolonged prothrombin time (PT) and partial thromboplastin time (PTT). The presumptive diagnosis was chronic hemolytic anemia. Platelet count and functions, fibrinogen, and factor XIII assays were all normal, but other factors assayed abnormally low; Sia water-dilution test was positive. When water-insoluble protein was removed by centrifugation, coagulation factors became normal. Dissolution of this precipitate in normal plasma caused marked prolongation of PT and PTT and lower factor assays. Serum electrophoresis showed a homogeneous M spike and an anomalous IgM, λ-antigenic type in the γ-globulin zone at point of origin. Ultracentrifugation of serum and of the precipitate showed 10% S17 and almost 100% S17 components, respectively. Five other patients with water-insoluble paraproteins were tested; two were clot-inhibitory. References 1. Lewis JH, Bayer WL, Curiel DC, et al: Hemorrhagic disease associated with circulating anticoagulants , in the Proceedings of the Fourth Congress of the Asian and Pacific Society of Hematology , India, pp 226-233, 1969. 2. Lewis JH, Szeto ILF, Ellis LD, et al: An acquired inhibitor to coagulation factor XIII. Johns Hopkins Med J 120:401-407, 1967. 3. Ferguson JH, Johnston CL Jr, Howell DA: A circulating inhibitor (Anti-AcG) specific for the labile factor-V of the blood-clotting mechanism. Blood 13:382-397,1958. 4. Sia RHP: Simple method for estimating quantitative differences in globulin precipitin test in kala-azar. Chin Med J 38:35, 1924. 5. Lewis JH: Hemostasis and hemorrhage. Sci Clin 1:1-66, 1971. 6. Lackner H: Hemostatic abnormalities associated with dysproteinemias. Semin Hematol 10:125-133, 1973. 7. Ritzmann SE, Wolf RE, Lawrence MC, et al: The Sia euglobulin test: A reevaluation. J Lab Clin Med 73:698-705, 1969.
TI - Water-Insoluble Paraproteins With Anticoagulant Properties
JF - Archives of Internal Medicine
DO - 10.1001/archinte.1975.00330080081013
DA - 1975-08-01
UR - https://www.deepdyve.com/lp/american-medical-association/water-insoluble-paraproteins-with-anticoagulant-properties-jdUC308QFw
SP - 1079
EP - 1081
VL - 135
IS - 8
DP - DeepDyve
ER -