TY - JOUR
AU1 - Madkour, Hassan
AU2 - El-Hashash, Maher
AU3 - Salem, Marwa
AU4 - Mahmoud, Al-Shimaa
AB - Developing novel antileishmanial, and cytotoxic drugs has been a significant area in modern pharmaceutical research. A series of novel triazolo[4,3-a]quinoline, triazino[4,3-a]quinoline, thiadiazepino[5,6-b]quinoline and pyrazolquinoline have been synthesized from the reaction of 2-hydrazinyltetrahydroquinoline-3-carbonitrile with formamide, formic acid, ethyl chloroacetate, carbon disulphide in an alcoholic solution of potassium hydroxide acetyl acetone and/or ethyl cyanoacetate, respectively. These compounds were evaluated for their in vitro studies against L. major leishmanial. The brine shrimp bioassay was also conducted to study their in vitro cytotoxic properties which displayed potent cytotoxic activity against Vincristine. The newly synthesized compounds were all characterized through IR, 1H-NMR, and MS.
TI - Synthesis, antileishmanial and cytotoxicity activities of fused and nonfused tetrahydroquinoline derivatives
JF - Research on Chemical Intermediates
DO - 10.1007/s11164-018-3311-6
DA - 2018-01-31
UR - https://www.deepdyve.com/lp/springer-journals/synthesis-antileishmanial-and-cytotoxicity-activities-of-fused-and-jbFskqBN86
SP - 3349
EP - 3364
VL - 44
IS - 5
DP - DeepDyve
ER -