TY - JOUR
AU - Aigner, J.
AB - In reconstructive surgery there is increasing demand for cartilage transplants to fill defects, especially nose and/or outer ear defects. Tissue engineering is one of the most modern pathways to generate autologous cartilage transplants. Isolated chondrocytes obtained from a tiny patient's biopsy were seeded on bioresorbable preshaped cell carriers to provide a 3-dimensional cell arrangement as in vivo. The combined use of these cell carriers in form of a non-woven mesh and a constant medium perfusion was performed to generate a cartilage-like cell-polymer-construct, which was finally subcutanously implanted in nude mice for full maturation. After explantation of 6 months, expression of cartilage specific extracellular matrix molecules was obvious by using histochemical and immunohistochemical methods. These data show that tissue engineering with isolated multiplied human chondrocytes from a tiny biopsy seeded on bioresorbable polymer is a promising system to generate autologous cartilage transplants for replacements in reconstructive surgery.
TI - Tissue Engineering of Autologous Cartilage Transplants for Rhinology
JF - American Journal of Rhinology
DO - 10.2500/105065898782102972
DA - 1998-01-01
UR - https://www.deepdyve.com/lp/sage/tissue-engineering-of-autologous-cartilage-transplants-for-rhinology-jZla20L5E5
SP - 59
EP - 64
VL - 12
IS - 1
DP - DeepDyve
ER -