TY - JOUR
AU - Padmanabhan,, Vasantha
AB - I. Introduction FOLLICLE-stimulating hormone (FSH), one of the major hormones produced by the anterior pituitary gland, is involved in the regulation and maintenance of essential reproductive processes, such as gametogenesis, follicular development, and ovulation (1–4). Like other glycoprotein hormones, FSH exists as a family of isohormones which have been identified within the anterior pituitary, serum, and urine of several mammalian species, including man (5–10) (Table 1). These isoforms differ in their oligosaccharide structures, including the degree of terminal sialylation and/or sulfation (5, 7, 9). The resulting acidic-basic charge differences provide the major basis for separation, with the number of isoforms identified often being a function of the resolution of the separation technique employed. Structural differences in these isoforms alter their MCRs and biological and immunological potency relationships (6–8). Consequently, target tissues within the gonads are exposed to a mixture of circulating FSH isoforms, the relative composition of which is dependent upon the physiological status of the animal (8–10, 39, 63, 67, 72). This content is only available as a PDF. Author notes † Current address: Director, General Clinical Research Center, NIH, Bethesda, Maryland 20892. Copyright © 1995 by The Endocrine Society
TI - Follicle-Stimulating Isohormones: Characterization and Physiological Relevance
JO - Endocrine Reviews
DO - 10.1210/edrv-16-6-765
DA - 1995-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/follicle-stimulating-isohormones-characterization-and-physiological-jZ0amiP9k2
SP - 765
EP - 787
VL - 16
IS - 6
DP - DeepDyve
ER -