TY - JOUR
AU - Vermeulen, A
AB - Administration of adrenocortical steroids is known to depress adrenocortical function. After Sayers & Sayers (1949) had demonstrated that adrenocortical steroids can inhibit the release of corticotrophin in response to stress and that adrenal extract does not inhibit the action of administered corticotrophin on the adrenal cortex of hypophysectomized animals, it has been assumed that adrenocortical depression was due to an inhibition of the secretion of corticotrophin.Boland & Headley (cit. in Coste et al., 1955) were the first to notice clinical signs of hypocorticism in patients previously treated with cortisone, whereas Forsham et al. (1950) reported biological signs of adrenocortical depression (low urinary 17-ketosteroid excretion) following cortisone therapy. Whereas before the discovery of cortisone, adrenal insufficiency was a relatively rare disease, its frequency has greatly increased since the therapeutic use of highly active glucocorticoid hormones. Fraser et al. (1952) and Salassa et al. (1953) reported fatal postoperative adrenocortical insufficiency in
TI - Adrenal Hypofunction after Corticoid Withdrawal
JF - European Journal of Endocrinology
DO - 10.1530/acta.0.0280321
DA - 1958-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/adrenal-hypofunction-after-corticoid-withdrawal-jW88fpc9Xu
SP - 321
EP - 330
VL - 28
IS - 3
DP - DeepDyve
ER -