TY - JOUR
AU1 - Cai, Guifang
AU2 - Anumanthan, Anukanth
AU3 - Brown, Julia A
AU4 - Greenfield, Edward A
AU5 - Zhu, Baogong
AU6 - Freeman, Gordon J
AB - CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly inhibited CD3- and CD28-mediated activation. We found that herpesvirus entry mediator (HVEM) was a ligand of CD160 that acted as a 'bidirectional switch' for T cell activation, producing a positive or negative outcome depending on the engagement of HVEM by CD160 and known HVEM ligands such as B and T lymphocyte attenuator (BTLA) and the T lymphocyte receptor LIGHT. Inhibition of CD4+ T cell activation by HVEM-transfected cells was dependent on CD160 and BTLA; when the cysteine-rich domain 1 of HVEM was deleted, this inhibition was lost, resulting in strong T cell activation. CD160 thus serves as a negative regulator of CD4+ T cell activation through its interaction with HVEM.
TI - CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
JF - Nature Immunology
DO - 10.1038/ni1554
DA - 2008-01-13
UR - https://www.deepdyve.com/lp/springer-journals/cd160-inhibits-activation-of-human-cd4-t-cells-through-interaction-jVGDsxhItx
SP - 176
EP - 185
VL - 9
IS - 2
DP - DeepDyve
ER -