TY - JOUR
AU - Hacein-Bey, Lotfi
AB -  Glutamate is an amino acid and one of a group of amino acid neurotransmitters in the brain, although it is the principal excitatory neurotransmitter. More basically, amino acids ( Fig 1 ) consist of a central carbon atom ( α carbon) bonded to a carboxyl group (COOH) and an amino group (NH 3 ). A distinctive side chain (R group), which characterizes each amino acid, links to the α carbon. Glutamate ( Fig 2 ) consists of the side chain CH 2 CH 2 COO - (COOH ending [ γ carboxyl group] for glutamic acid) attached to the α carbon, while the closely related glutamine ( Fig 3A and B ) is created from glutamate with ammonia added at the γ carboxyl group by glutamine synthetase, forming the CH 2 CH 2 CONH 2 side chain R group. Cerebral glutamate is derived solely from endogenous sources; mainly from α ketoglutarate, which is a product of the Krebs cycle (citric acid cycle, TCA [tricarboxylic acid] cycle). View larger version: In this window In a new window fig 1. Amino acid. Typical amino acid consists of a central alpha carbon ( Cα ) that is bonded to a carboxyl group 
TI - Pictorial Review of Glutamate Excitotoxicity: Fundamental Concepts for Neuroimaging
JF - American Journal of Neuroradiology
DA - 2001-11-01
UR - https://www.deepdyve.com/lp/american-journal-of-neuroradiology/pictorial-review-of-glutamate-excitotoxicity-fundamental-concepts-for-jQnmrmSHci
VL - 22
IS - 10
DP - DeepDyve
ER -