TY - JOUR
AU - Lambert, R.
AB - 5 human cases of hepatoma have been chosen with respect to their different seric α-fetoprotein (α-FP) level and histological characters. Cells producing α-FP have been studied with specific horseradish-peroxidase-labelled immunoglobulins. Ultrastructural examination shows that α-FP is present in the cytoplasm of some tumoral hepatocytes. α-FP is also present in the cytoplasm of some rare nontumoral hepatocytes of a nonsecreting hepatoma. Ultrastructural differences are described in tumoral hepatocytes according to the grade of differentiation of the tumoral cell population. α-FP production appears to be restricted to moderately differentiated tumoral hepatocytes. These observations led to the hypothesis that production of α-FP may transiently develop either during the differentiation of tumoral hepatocytes, or during the new differentiation of nontumoral hepatocytes involved in a proliferatíve process.
TI - Tissular Immunoenzymatic Detection of Hepatic Alphafetoprotein in Human Hepatomas
JF - Digestion
DO - 10.1159/000198222
DA - 1978-01-01
UR - https://www.deepdyve.com/lp/karger/tissular-immunoenzymatic-detection-of-hepatic-alphafetoprotein-in-jNFvrcA3N7
SP - 351
EP - 370
VL - 18
IS - 5-6
DP - DeepDyve
ER -