TY - JOUR
AU - Elsayed, Rasha
AB - 
N-sulfonylamino azinones has attracted the interest of numerous researchers and extensive investigations on their biological activities have been done. The present review provides an overview of the patents and reports filed during the last few years pertaining to the synthesis N-sulfonyl azinones as well as their biological and preclinical studies. A brief discussion on the significant biological findings is also provided. It has been established that N-sulfonylamino azinones is privileged heterocycles possessing diuretic, antihypertensive, anti-inflammatory, and anticancer and other biological activities. In particular, a new generation of competitive AMPA receptor antagonist based on N-sulfonylamino 1H-quinazoline-2,4-diones is promising useful in the treatment neurological disorders such as epilepsy and schizophrenia. The scope of these new advances has been also highlighted in this review.
TI - Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018)
JF - Medicinal Chemistry Research
DO - 10.1007/s00044-019-02378-6
DA - 2019-06-12
UR - https://www.deepdyve.com/lp/springer-journals/sulfa-drug-analogs-new-classes-of-n-sulfonyl-aminated-azines-and-their-jF90oAyraI
SP - 1099
EP - 1131
VL - 28
IS - 8
DP - DeepDyve
ER -