TY - JOUR AU1 - Lieberman, S AU2 - Dobriner, K AB - of the biologically essentially C-ll oxygen function into the steroid nucleus had not been accomplished. As a result of the brilliant work of Reichstein , Kendall, Gal l agher, and Win terstein er in the middle forties, t h is objective mones became practicable. Fin ally, large amounts were made available for extensive inve st igatio ns. At about the same time the adrenfll-stimulating and Julian, the large scale preparation of the most important cortical hor­ was achieved and together with the further contributions· of these investig a­ tors, as well as the very significant achievements of Sarett, Miescher, Wallis, hormone of the pituitary (ACTH) became available in sufficient amounts and in a usable stage of purity so that both hormones were at hand for the study of the essential physiological processes controlled by the internal secre­ tions of the adrenal. Within an extremely short time the epoch-making dis­ covery of Hench and Kendall of the effect of these hormones in arthritis was reported. These observations opened a new era in medicine, physiology and biochemistry, and it was reco gnized as such by the award of the Nobel prize to Reichstein, Kendall, and Hench in 1950. The number TI - Biochemistry of Steroids JF - Annual Review of Biochemistry DO - 10.1146/annurev.bi.20.070151.001303 DA - 1951-07-01 UR - https://www.deepdyve.com/lp/annual-reviews/biochemistry-of-steroids-jBJ2TyrVTM SP - 227 EP - 264 VL - 20 IS - 1 DP - DeepDyve ER -