TY - JOUR
AU - SMITH, Ian E.
AB - ABSTRACT Background and objective: Volume‐assured non‐invasive positive pressure ventilation (va‐NIPPV) is a novel mode designed to adapt pressure support (PS) to achieve a target minute ventilation (TgV). This may optimize ventilation; however, no data confirm that va‐NIPPV compensates appropriately for the changes in pulmonary mechanics and circuit leak seen in clinical practice. Bench testing assessed these principles. Methods: A ventilator featuring a va‐NIPPV mode was studied. A test lung with varying compliance and resistance, and pneumotachograph were used. Eight lung model settings were chosen: (i) low resistance and high compliance; (ii) low resistance and low compliance; (iii) high resistance and high compliance; and (iv) high resistance and low compliance, all with and without additional circuit leak. An expiration valve, respiratory rate of 15, inspiratory time of 1 s and PS between 3 and 21 cm H2O were used. Va‐NIPPV was tested with varying TgV after establishing the range of minute ventilation possible in a pressure preset mode. Results: At a TgV of 10 L/min, va‐NIPPV delivered minute ventilation of (median (interquartile range) ): 11 (10.9–11, 10.2 (10.2–10.3), 12.4 (12.4–12.4) and 11.2 (10.9–11.2) L/min in test lung settings 1, 2, 3 and 4, respectively. Additional leak between 8–33 L/min had little effect. Similar results were seen at other TgV, within the ventilator's PS capabilities. Conclusions: These data confirm that va‐NIPPV is able to approximate a preset TgV with varying lung compliance and resistance, and that additional circuit leak has little effect on the delivered minute ventilation.
TI - A bench test to confirm the core features of volume‐assured non‐invasive ventilation
JF - Respirology
DO - 10.1111/j.1440-1843.2009.01691.x
DA - 2010-02-01
UR - https://www.deepdyve.com/lp/wiley/a-bench-test-to-confirm-the-core-features-of-volume-assured-non-jAciG7f2I9
SP - 361
VL - 15
IS - 2
DP - DeepDyve
ER -