TY - JOUR
AU1 - Imamoto, Tsuneo
AB - In this account, the design, synthesis, and application of P‐chirogenic phosphine ligands that have been mainly carried out in our laboratory over the last three decades are described. Various enantiopure P‐chirogenic phosphine ligands have been efficiently prepared by using phosphine boranes as intermediates. Conformationally rigid and electron‐rich P‐chirogenic phosphine ligands possessing C2 symmetry as well as a bulky alkyl group and a small group at the phosphorus atoms exhibit excellent enantioselectivities and catalytic efficiency in a variety of transition‐metal‐catalyzed asymmetric reactions. Enantiopure 2,3‐bis(tert‐butylmethylphosphino)quinoxaline (QuinoxP*) is an air‐stable crystalline solid that shows superior enantioinduction ability in catalytic asymmetric syntheses. Mechanistic studies of Rh‐catalyzed asymmetric hydrogenation using structurally simple P‐chirogenic phosphine ligands, such as tBu‐BisP*, are briefly described.







TI - Searching for Practically Useful P‐Chirogenic Phosphine Ligands
JF - The Chemical Record
DO - 10.1002/tcr.201600098
DA - 2016-12-01
UR - https://www.deepdyve.com/lp/wiley/searching-for-practically-useful-p-chirogenic-phosphine-ligands-j9zkJrQbw2
SP - 2655
EP - 2669
VL - 16
IS - 6
DP - DeepDyve
ER -