TY - JOUR AU - Clark, Leon A. AB - The relation between humoral and cellular immune responses to measles virus inCercopithecus aethiops monkeys was examined by in vitro virus neutralization andcolony inhibition techniques. Both types of specific immune response were maximaltwo or three weeks after infection and then declined at similar rates for severalweeks. However, the humoral response persisted at a low level for at least 44weeks, whereas the cell-mediated response became undetectable as early as 10weeks after infection. The cellular response disappeared in three monkeys (includingone monkey that produced no detectable circulating antibody) after natural infectionas well. Second inoculations with measles virus produced a rise in titer of antibody, butthe cellular response was weak or lacking. However, there appeared to be a significantincrease in the capacity oflymphocytes from these animals to attach in vitro to measlesvirus-infected cells. Antiserum to measles virus blocked this phenomenon. TI - Neutralizing Antibody and Lymphocyte-Mediated, Colony-Forming Inhibition Responses to Measles Infection in Cercopithecus aethiops Monkeys JF - The Journal of Infectious Diseases DO - 10.1093/infdis/132.5.511 DA - 1975-11-01 UR - https://www.deepdyve.com/lp/oxford-university-press/neutralizing-antibody-and-lymphocyte-mediated-colony-forming-j4E80NPG2D SP - 511 EP - 519 VL - 132 IS - 5 DP - DeepDyve ER -