TY - JOUR
AU1 - Gregory, David Alexander
AU2 - Fricker, Annabelle T. R.
AU3 - Mitrev, Peter
AU4 - Ray, Meghna
AU5 - Asare, Emmanuel
AU6 - Sim, Daniel
AU7 - Larpnimitchai, Soponvit
AU8 - Zhang, Zixuan
AU9 - Ma, Jinge
AU1 - Tetali, Santosh S. V.
AU1 - Roy, Ipsita
AB - In the last few decades Additive Manufacturing has advanced and is becoming important for biomedical applications. In this study we look at a variety of biomedical devices including, bone implants, tooth implants, osteochondral tissue repair patches, general tissue repair patches, nerve guidance conduits (NGCs) and coronary artery stents to which fused deposition modelling (FDM) can be applied. We have proposed CAD designs for these devices and employed a cost-effective 3D printer to fabricate proof-of-concept prototypes. We highlight issues with current CAD design and slicing and suggest optimisations of more complex designs targeted towards biomedical applications. We demonstrate the ability to print patient specific implants from real CT scans and reconstruct missing structures by means of mirroring and mesh mixing. A blend of Polyhydroxyalkanoates (PHAs), a family of biocompatible and bioresorbable natural polymers and Poly(L-lactic acid) (PLLA), a known bioresorbable medical polymer is used. Our characterisation of the PLA/PHA filament suggest that its tensile properties might be useful to applications such as stents, NGCs, and bone scaffolds. In addition to this, the proof-of-concept work for other applications shows that FDM is very useful for a large variety of other soft tissue applications, however other more elastomeric MCL-PHAs need to be used.
TI - Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices
JF - Journal of Functional Biomaterials
DO - 10.3390/jfb14010040
DA - 2023-01-10
UR - https://www.deepdyve.com/lp/pubmed-central/additive-manufacturing-of-polyhydroxyalkanoate-based-blends-using-ilCu8Aaqwc
VL - 14
IS - 1
DP - DeepDyve
ER -