TY - JOUR
AU - Koehler, Peter
AB - We report a 71-year-old woman who presented with a cerebral cavernous malformation in the right frontal lobe for which she underwent total resection. Three years later, she was admitted with seizures and neuroimaging revealed a partially calcified lesion in the area of the earlier cavernous malformation, consistent with a residual malformation. A few months later she presented with cognitive decline and neuroimaging now revealed a large mass lesion in the same area as the cavernous malformation, irregularly enhancing, spreading through the corpus callosum to the left frontal lobe. Histological examination showed an anaplastic oligo-astrocytoma. These findings suggest that cerebral cavernous malformations, or at least a subgroup, have the potential for oligodendrocytic and astrocytic transformation. Various hypotheses to explain the etiology of these rare cases are discussed.
TI - Anaplastic oligo-astrocytoma occurring after resection of a cerebral cavernous malformation; malignant transformation? Case report and review on etiology
JO - Journal of Neurology
DO - 10.1007/s00415-009-5322-0
DA - 2009-09-24
UR - https://www.deepdyve.com/lp/springer-journals/anaplastic-oligo-astrocytoma-occurring-after-resection-of-a-cerebral-iX9v7gcW83
SP - 349
EP - 353
VL - 257
IS - 3
DP - DeepDyve
ER -