TY - JOUR
AU - DeChatelet, Larry
AB - The function of toxic neutrophils from patients with severe infection and inflammation was studied by in-vitro determination of their chemotactic, migratory, phagocytic, and bactericidal activities. Toxic neutrophils had 21% of the chemotactic activity of controls. Staphylococcus albus was destroyed less readily by toxic neutrophils, but the differences observed between toxic and control neutrophils were small. After incubation for 2 hr, toxic neutrophils killed 81% of the original inoculum, while control cells killed 97 %. This small reduction in total bacterial clearance by toxic neutrophils was associated with increases in both free and cell-associated bacteria, suggesting a compromise in phagocytic and bactericidal activities. Sera from patients with toxic neutrophils did not affect normal neutrophils. Studies of phagocytes from ten patients who had febrile illnesses without toxic neutrophils were normal. None of these patients had severe bacterial infection. No alterations in function were detected in neutrophils of two patients with polycythemia vera and one with myeloid metaplasia.
TI - Functional Characteristics of Human Toxic Neutrophils
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/124.1.68
DA - 1971-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/functional-characteristics-of-human-toxic-neutrophils-iWcyMtIvRW
SP - 68
EP - 75
VL - 124
IS - 1
DP - DeepDyve
ER -