TY - JOUR
AU1 - Petrick, Lauren
AU2 - Edmands, William
AU3 - Schiffman, Courtney
AU4 - Grigoryan, Hasmik
AU5 - Perttula, Kelsi
AU6 - Yano, Yukiko
AU7 - Dudoit, Sandrine
AU8 - Whitehead, Todd
AU9 - Metayer, Catherine
AU1 - Rappaport, Stephen
AB - Metabolomics (2017) 13:27 DOI 10.1007/s11306-016-1153-z ORIGINAL ARTICLE An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies 1 1 2 1 Lauren Petrick  · William Edmands  · Courtney Schiffman  · Hasmik Grigoryan  · 1 1 2,3 4,5 Kelsi Perttula  · Yukiko Yano  · Sandrine Dudoit  · Todd Whitehead  · 4,5 1,5 Catherine Metayer  · Stephen Rappaport   Received: 13 October 2016 / Accepted: 16 December 2016 / Published online: 3 February 2017 © Springer Science+Business Media New York 2017 Abstract chromatography—high resolution mass spectrometry (LC- Introduction For pediatric diseases like childhood leuke- HRMS) and an untargeted workflow was used to screen mia, a short latency period points to in-utero exposures as for metabolites that discriminate population characteristics potentially important risk factors. Untargeted metabolomics such as sex, ethnicity, and birth weight. of small molecules in archived newborn dried blood spots Results Thousands of small molecules were measured (DBS) offers an avenue for discovering early-life exposures in extracts of archived DBS. Normalizing for potassium that contribute to disease risks. levels removed variability related to varying hematocrit Objectives The purpose of this study was to develop a across DBS punches. Of the roughly 1000 prevalent small quantitative method for untargeted analysis of archived molecules that were tested, multivariate linear regres- newborn 
TI - An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies
JF - Metabolomics
DO - 10.1007/s11306-016-1153-z
DA - 2017-02-03
UR - https://www.deepdyve.com/lp/springer-journals/an-untargeted-metabolomics-method-for-archived-newborn-dried-blood-iDPs0SUxa9
SP - 1
EP - 11
VL - 13
IS - 3
DP - DeepDyve
ER -