TY - JOUR
AU1 - Liu, Kang
AU2 - Qin, Zhongke
AU3 - Ge, Yifei
AU4 - Bian, Ao
AU5 - Xu, Xueqiang
AU6 - Wu, Buyun
AU7 - Xing, Changying
AU8 - Mao, Huijuan
AB - PurposeImmune checkpoint inhibitor (ICI) therapy is now the stand of care for lung cancer. Due to the low incidence, the study of acute kidney injury (AKI) in lung cancer patients treated with ICIs was hardly reported. We focused on the incidence, characteristics, risk factors, and mortality of AKI in advanced lung cancer patients receiving PD-1 inhibitors.MethodsWe reviewed advanced lung cancer patients receiving PD-1 inhibitors between January 2018 to August 2020 at Jiangsu Province Hospital. Patients were followed up for 6 months. We used the logistic regression model to evaluate risk factors for AKI, and Kaplan–Meier method to assess the association between AKI and mortality.ResultsA total of 305 advanced lung cancer patients treated with PD-1 inhibitors. The median age was 64 years and 80.6% of patients were male. The incidence of AKI was 10.2%, and the incidence of ICI-AKI was 4.6%. Multivariate analysis showed that concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) (OR 2.509; 95% CI 1.053–5.974) and renin–angiotensin–aldosterone system (RAAS) inhibitors (OR 2.656; 95% CI 1.091–6.466) were risk factors for AKI. In addition, concomitant use of NSAIDs (OR 5.170; 95% CI 1.087–24.595) and RAAS inhibitors (OR 5.921; 95% CI 1.871–18.737), and the occurrence of extra-renal immune-related adverse events (OR 4.726; 95% CI 1.462–15.280) were significantly associated with ICI-AKI. ICI-AKI was not associated with mortality while severe AKI was associated with higher risk of mortality.ConclusionAKI is common in advanced lung cancer patients treated with PD-1 inhibitors. The characteristics and risk factors of ICI-AKI were similar to those previously reported in other solid organ malignancies treated with ICIs. Severe AKI may indicate higher mortality.
TI - Acute kidney injury in advanced lung cancer patients treated with PD-1 inhibitors: a single center observational study
JF - Journal of Cancer Research and Clinical Oncology
DO - 10.1007/s00432-022-04437-9
DA - 2023-07-01
UR - https://www.deepdyve.com/lp/springer-journals/acute-kidney-injury-in-advanced-lung-cancer-patients-treated-with-pd-1-i9pjBD22Ow
SP - 5061
EP - 5070
VL - 149
IS - 8
DP - DeepDyve
ER -