TY - JOUR
AU - Sowton,, E.
AB - Abstract Although both nitrates and calcium antagonists may be administered by the intracoronary route, the relative efficacy of these agents and of their combination is unknown. In this study, we investigated the coronary vasodilatory potential of intracoronary nifedipine, isosorbide dinitrate and their combination in patients undergoing routine coronary arteriography. Both normal and diseased segments of coronary arteries were studied. Coronary artery diameters were measured from 35 mm cine film before and after the administration of each drug. Two groups of 10 patients were studied: group I received nifedipine, 0.2 mg, followed by isosorbide dinitrate, 1 mg, group 11 received isosorbide dinitrate, 1 mg, followed by nifedipine, 0.2 mg. Both agents resulted in significant dilatation of normal and diseased segments of the coronary arteries when injected as the first drug, but neither nifedipine nor isosorbide dinitrate produced significant additional vasodilation when injected as the second drug. The degree of dilatation of both diseased and normal segments produced by either nifedipine or isosorbide dinitrate was similar, suggesting that the dose used, of either drug, produced near maximal coronary vasodilatation. Importantly, drug induced dilatation of stenotic segments was similar to that of normal segments. Coronary angiography, coronary vasodilator, isosorbide dinitrate, nifedipine This content is only available as a PDF. © 1987 The European Society of Cardiology
TI - Coronary dilator effects of intracoronary nifedipine and isosorbide dinitrate
JF - European Heart Journal
DO - 10.1093/eurheartj/8.suppl_K.69
DA - 1987-11-01
UR - https://www.deepdyve.com/lp/oxford-university-press/coronary-dilator-effects-of-intracoronary-nifedipine-and-isosorbide-i37ZY2h1KU
SP - 69
EP - 74
VL - 8
IS - suppl_K
DP - DeepDyve
ER -