TY - JOUR
AB -  A m 2 ELEVATION OF INTRACELLULAR cAMP IN HUMAN T LYMPHOCYTES BY AN ANTI-CD44 mAb. Barbara L. Rothman. Nancy Kennure. Keith A. Kelley. Michael Katz and Thomas M. Aune. Miles Research Center. West Haven, CT 06516. Regulation o f lymphocyte responses to activation of the CD3-T cell receptor complex by other cell surface proteins expressed on l y m p h o c y t e s is a well established phenomenon. CD44 is an example of such a cell surface protein. Anu-CD44 mAb's have been identified which either stimulate o r inhibit lymphocyte function. Certain anti-CD44 mAb's augment pmliferation and ILZ production by T cells stimulated through CD2 o r C D 3 - T cell receptor An anti-CD44 mAb inhibits activation of pathways. human T cells by preventing the rise in [ C a + + li stimulated by OKT3. The purpose of experiments reported here was to further characterize this phenomenon. T h e results show that the anti-CD46 mAb. 212.3. d o e s not inhibit inositol phosphate turnover stimulated by O K T 3 but d o e r inhibit elevation of intracellular [Ca++]i in Ihese same cells. Addition of 212.3 to purified 
TI - Adhesion Structures AS001‐AS162
JF - Tissue Antigens
DO - 10.1111/j.1399-0039.1993.tb02189.x
DA - 1993-09-01
UR - https://www.deepdyve.com/lp/wiley/adhesion-structures-as001-as162-hzD6do4kHu
SP - 257
VL - 42
IS - 3
DP - DeepDyve
ER -