TY - JOUR
AU1 - Tabet, Stephen R.
AU2 - Goldbaum, Gary M.
AU3 - Hooton, Thomas M.
AU4 - Eisenach, Kathleen D.
AU5 - Cave, M. Donald
AU6 - Nolan, Charles M.
AB - Analysis of restriction fragment length polymorphisms (RFLP) was used to investigate an increase in tuberculosis (TB) among noninstitutionalized human immunodeficiency virus (HIV)-infected persons in King County, Washington. Using the IS6110 insertion sequence, RFLP analysis was done on Mycobacterium tuberculosis isolates from 18 HIV-infected patients and 10 randomly selected patients without HIV risk factors. Six HIV-infected patients with the same M. tuberculosis strain had contact at one or more of three bars as their only common exposure. Two other HIV-infected persons, a patient and a health care worker who had close contact, had matching strains. Isolates from the 10 remaining HIV-infected patients and the 10 patients without HIV risk factors had different DNA patterns. Analysis of RFLP patterns revealed a community outbreak of TB among HIV-infected persons who had not been previously linked following conventional investigation by the health department. This technique deserves further evaluation as an epidemiologic tool in the investigation of TB.
TI - Restriction Fragment Length Polymorphism Analysis Detecting a Community-Based Tuberculosis Outbreak among Persons Infected with Human Immunodeficiency Virus
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/169.1.189
DA - 1994-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/restriction-fragment-length-polymorphism-analysis-detecting-a-hwl1fmbi0S
SP - 189
EP - 192
VL - 169
IS - 1
DP - DeepDyve
ER -