TY - JOUR
AU - Herscheid, J. D. M.
AB -  LABELING OF ["F]FLUMAZENIL VIA INSTANT FLUORINATION, A NEW NUCLEOPHILIC FLUORINATION METHOD A.D. Windhorst, R.P. Klok, C. L. Koolen, G.W.M. Visser, J.D.M. Herscheid Radiomielide Center, Vrije Uiiiversiteit, De Boelelnari 1085c, 1081 H V Atiisterdam, The Netherlands Key Words: Flumazenil, "F, aromatic nucleophilic fluorination Introduction ["C]Flumazenil is a widely used PET radioligand for the central GABAA benzodiazepine receptor and is used both in the clinic to determine epileptic foci and in research studies, e.g. for elucidation of depression processes in the brain( 1-5). '% N la, R = F,Flumazenil Ib,R=NOz At our center a Siemens HRRT PET scanner has recently been installed. This high resolution PET camera will be used for small animal PET studies. A high specific activity is needed for high-resolution PET studies of receptor systems(6). However, with the current production techniques of ["CJ labeled receptor ligands only a specific activity of around 100 GBq/pmol at time of injection is obtained. Therefore one of the main research themes at our center is the development of "Flabeled PET tracers via nucleophilic fluorination reactions, eliminating the problem of the specific activity. Another advantage of the use of "F is the longer half-life compared to " C which enables more prolonged 
TI - Labeling of ( 18 F)flumazenil via instant fluorination, a new nucleophilic fluorination method
JF - Journal of Labelled Compounds and Radiopharmaceuticals
DO - 10.1002/jlcr.25804401327
DA - 2001-05-01
UR - https://www.deepdyve.com/lp/wiley/labeling-of-18-f-flumazenil-via-instant-fluorination-a-new-hqVvqWeDi7
SP - S930
EP - S932
VL - 44
IS - S1
DP - DeepDyve
ER -