TY - JOUR
AU - Norden, Carl W.
AB - Levels of rifampin, gentamicin, sisomicin, and cephalothin in normal and osteomyeliticrabbit bones were measured, and the efficacy of these drugs in the treatment ofosteomyelitis was evaluated. Single drug regimens, including rifampin for 14days andgentamicin, sisomicin, and cephalothin each for 28 days, were relatively ineffective(5%-33% sterile bone cultures). Rifampin, administered for 28 days, sterilized thebones of 55% of treated animals. The combination of gentamicin and rifampin, givenfor either 14 or 28 days, sterilized the bones of 67% of treated animals. The combinationsof rifampin plus sisomicin and of rifampin plus cephalothin, given for 28 days,were significantly more effective than these agents alone, sterilizing 90%-95% ofbones. The combination of rifampin, sisomicin, and cephalothin, given for only 14days, sterilized the bones of all treated rabbits. Staphylococci isolated from the bonesof therapeutic failures that had received rifampin alone or in combination with otherantibiotics were highly resistant to rifampin (minimal inhibitory concentration, >250µg/ml) , whereas the organisms recovered from animals not receiving rifampinremained sensitive. Results of in vitro studies of synergy and/or bactericidal activity ofantibiotic combinations correlated with in vivo results in some, but not all, instances.
TI - Experimental Osteomyelitis. IV. Therapeutic Trials with Rifampin Alone and in Combination with Gentamicin, Sisomicin, and Cephalothin
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/132.5.493
DA - 1975-11-01
UR - https://www.deepdyve.com/lp/oxford-university-press/experimental-osteomyelitis-iv-therapeutic-trials-with-rifampin-alone-hm4RhV2SEz
SP - 493
EP - 499
VL - 132
IS - 5
DP - DeepDyve
ER -