TY - JOUR
AU1 - Hattori, Kyosuke
AU2 - Takahashi, Nobunori
AU3 - Kojima, Toshihisa
AU4 - Imagama, Shiro
AB - ABSTRACTObjectivesTo investigate efficacy of long-term treatment with denosumab and predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis (PMO).MethodsWe enrolled 111 PMO patients who had T-scores ≤−2.5 either at the lumbar spine (L-) or femoral neck (FN-), who had never been treated for osteoporosis, and who could be followed for at least 3 years. We first evaluated changes in bone mineral density (BMD) for up to 7 years. We next defined the treatment goal as the achievement of a T-score >−2.5 at month 36 and performed multivariate analysis to identify predictive factors for achievement of the goal.ResultsLumbar spine- and femoral neck bone-mineral density increased yearly for 7 years. Among 87 patients with baseline L-T-scores ≤−2.5, better baseline L-T-scores predicted achievement of L-T-scores >−2.5 at month 36. The cut-off value for baseline L-T-score was −3.4. Among 76 patients with baseline FN-T-scores ≤−2.5, better baseline FN-T-scores predicted achievement of FN-T-scores >−2.5 at month 36. The cut-off value for baseline FN-T-scores was −2.8.ConclusionsLong-term treatment with denosumab was effective in PMO patients. As better baseline T-score predicted achievement of T-scores >−2.5, early initiation of treatment will contribute to better outcome.
TI - Predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis treated with denosumab
JF - Modern Rheumatology
DO - 10.1093/mr/roab129
DA - 2021-12-22
UR - https://www.deepdyve.com/lp/oxford-university-press/predictive-factors-for-achievement-of-treatment-goals-in-patients-with-hdlZ31ndvm
SP - 217
EP - 223
VL - 33
IS - 1
DP - DeepDyve
ER -