TY - JOUR
AU - Elizan, Teresita, S.
AB - Abstract C-57 albino weanling mice were latently infected with herpes simplex virus (Mp strain, type 1) by inoculation of 104 plaque forming units in the right hind footpad. The virus was demonstrable in explant cultures of the sacral dorsal root ganglia of these mice for as long as 18 months following inoculation. In addition, the virus was detectable when homogenates of these latently infected ganglia were placed on to differentiated organotypic cultures of fetal mouse dorsal root ganglia for as long as 8 months following inoculation of the mice. Virus was not demonstrable in these homogenates when they were placed on to Hela cells. The results suggest that during herpes simplex virus latent infection in mice there is continuous synthesis of infectious virus, probably in a highly localized area, which is detectable if a sensitive indicator substrate, such as these organotypic cultures, is used. This content is only available as a PDF. Copyright © 1978 by The Association of the Journal of Neuropathology and Experimental Neurology Inc.
TI - Latent Herpes Simplex Virus Infection of MiceInfectious Virus in Homogenates of Latently Infected Dorsal Root Ganglia
JF - Journal of Neuropathology & Experimental Neurology
DO - 10.1097/00005072-197801000-00004
DA - 1978-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/latent-herpes-simplex-virus-infection-of-miceinfectious-virus-in-hcHwUJavjw
SP - 45
EP - 55
VL - 37
IS - 1
DP - DeepDyve
ER -