TY - JOUR
AU - Chen, Kevin P.
AB - This paper introduces a rapid prototyping method for fabricating microfluidic devices with integrated on-chip pumps and valves using layer-by-layer manufacturing. The process enables the use of biocompatible materials such as medical-grade adhesive tapes, PMMA, and thermoplastics, micromachined with ultraviolet lasers for precision and versatility. Devices are assembled layer by layer in a bio-safety hood, ensuring sterility and compatibility with sensitive applications. Demonstrating bi-directional pneumatic pumps with controllable flow rates up to 230 μL/min, this approach streamlines the integration of multiple materials, enhancing functionality and accessibility. The device was used to perform isletdifferentiated iPSCs culture, maintaining cell health and viability in 7-day culture. It offers a practical solution for advancing technologies in organ-on-a-chip (OoC) systems, point-of-care diagnostics, and environmental monitoring.
TI - Rapid prototyping of microfluidic on-chip valves and pumps for biomedical applications
JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
DO - 10.1117/12.3042286
DA - 2025-03-20
UR - https://www.deepdyve.com/lp/spie/rapid-prototyping-of-microfluidic-on-chip-valves-and-pumps-for-hbhGorANTo
SP - 133120A
EP - 133120A-4
VL - 13312
IS - 
DP - DeepDyve
ER -