TY - JOUR
AU1 - Wu, Shanshan
AU2 - Xie, Sian
AU3 - Yuan, Changzheng
AU4 - Yang, Zhirong
AU5 - Liu, Si
AU6 - Zhang, Qian
AU7 - Sun, Feng
AU8 - Wu, Jing
AU9 - Zhan, Siyan
AU1 - Zhu, Shengtao
AU1 - Zhang, Shutian
AB - BackgroundThis study aims to examine the prospective association of inflammatory bowel disease (IBD) with long-term risk of overall, site-specific cancer and cancer-specific mortality in middle-aged and older people.MethodsThe study included participants free of any cancer at baseline from the UK Biobank, with IBD patients as an exposure group and non-IBD patients as a reference group. Primary outcome was the incidence of overall cancer and cancer-specific mortality. Secondary outcomes included site-specific cancers and types of digestive cancers. Cox proportional hazard model was used to investigate the associated risk of incident malignancies and related mortality.ResultsAmong 455 927 participants, 5142 were diagnosed with IBD (3258 ulcerative colitis [UC]; 1449 Crohn’s disease [CD]; others unspecified). During a median of 12.2-year follow-up, 890 cases of incident cancer were identified in IBD patients (15.74 per 1000 person years) compared with 63 675 cases in reference individuals (12.46 per 1000 person years). Of these cases, 220 and 12 838 cancer-specific deaths occurred in IBD and non-IBD groups. Compared with non-IBD participants, the adjusted hazard ratio (AHR) for overall cancer and cancer-specific mortality was 1.17 (95% CI, 1.09-1.25) and 1.26 (95% CI, 1.18-1.35) among IBD patients, with an AHR of 1.15 (95% CI, 1.02-1.31) and 1.38 (95% CI, 1.08-1.75) in UC and 1.15 (95% CI, 1.06-1.25) and 1.25 (95% CI, 1.06-1.49) in CD, respectively. Specifically, increased risk of digestive (1.33; 95% CI, 1.12-1.57), nonmelanoma (1.25; 95% CI, 1.11-1.41), and male genital (1.29; 95% CI, 1.09-1.52) cancers was observed in IBD patients.ConclusionsCompared with non-IBD, IBD may be associated with an increased risk of overall cancer and cancer-specific mortality, particularly digestive cancers, nonmelanoma and male genital cancers.
TI - Inflammatory Bowel Disease and Long-term Risk of Cancer: A Prospective Cohort Study Among Half a Million Adults in UK Biobank
JF - Inflammatory Bowel Diseases
DO - 10.1093/ibd/izac096
DA - 2022-05-27
UR - https://www.deepdyve.com/lp/oxford-university-press/inflammatory-bowel-disease-and-long-term-risk-of-cancer-a-prospective-hUQAFBPeTF
SP - 384
EP - 395
VL - 29
IS - 3
DP - DeepDyve
ER -