TY - JOUR
AU - BEARD, EDMUND, E.
AB - Abstract THE GROWTH PATTERN of an individual is the resultant of a number of forces. Among the factors intrinsic to the organism are the “inherent growth impulse,” the thyroid hormone, and a pituitary principle which has been called the growth hormone. Whether or not there may occur in man a constitutional defect of the growth impulse (as might be suggested in some cases of dwarfism by failure to find any other lack and by failure to stimulate growth by thyroid and pituitary preparations) is not known. That dwarfism may occur as the result of either thyroid or pituitary deficiency is abundantly shown both in the laboratory and in the clinic. An accumulation of evidence shows that the pituitary and thyroid are closely interrelated in their metabolic and growth affecting functions. MacCallum and Fabyan (1) described shrunken eosinophilic cells in the pituitary of a human cretin. Zweckwer, Davison, Keller and Livingood (2) ascribed cretinic dwarfism to loss of eosinophils from the pituitary secondary to loss of thyroid function. Severinghaus, Smelser and Clark (3) found that there is a loss of eosinophils and impairment of the anterior pituitary in thyroidectomized animals. It is well known, of course, that human beings or animals dwarfed by loss of thyroid function respond with dramatic growth to thyroid feeding. In the absence of the pituitary, however, daily injection of thyroid substance is unable to stimulate growth (4), whereas thyroidectomized animals grow rapidly and continuously when injected with pituitary growth hormone (5). Smith (6) has shown that in the thyroidectomized and hypophysectomized animal more rapid growth will take place if thyroid and hypophyseal extract are given than if the growth principle alone is used. This content is only available as a PDF. Copyright © 1941 by The Endocrine Society
TI - LACK OF RESPONSE TO ANTERIOR PITUITARY GROWTH PRINCIPLE
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jcem-1-4-293
DA - 1941-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/lack-of-response-to-anterior-pituitary-growth-principle-hJopEnJ60d
SP - 293
EP - 296
VL - 1
IS - 4
DP - DeepDyve
ER -