TY - JOUR
AU1 - Takahashi, Toru
AU2 - Sano, Kaori
AU3 - Suzuki, Tadaki
AU4 - Matsumura, Takuro
AU5 - Sakai, Kohei
AU6 - Tominaga, Takayuki
AU7 - Sato, Yuko
AU8 - Katano, Harutaka
AU9 - Hasegawa, Hideki
AB - Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral hemorrhagic disease with a high fatality rate. It is caused by the SFTS virus and is endemic in East Asian countries such as China, South Korea, and Japan. Previous studies have shown that plasmablasts appear transiently in peripheral blood during the acute phase of SFTS, but do not specify the characteristics of these plasmablasts. In this report, we describe the features of peripheral blood plasmablasts in a patient with SFTS. Immunohistochemical and immunofluorescence staining detected a small number of atypical lymphocytes expressing the SFTS virus antigen among peripheral leukocytes in a blood sample. The phenotype of the virus-infected cells was CD27+, CD38+, MUM1+, and CD138+, which is consistent with that of plasmablasts. This novel study demonstrates that plasmablasts in the peripheral blood of patients with SFTS are targets of the SFTS virus.
TI - Virus-infected peripheral blood plasmablasts in a patient with severe fever with thrombocytopenia syndrome
JF - International Journal of Hematology
DO - 10.1007/s12185-020-03040-3
DA - 2020-11-22
UR - https://www.deepdyve.com/lp/springer-journals/virus-infected-peripheral-blood-plasmablasts-in-a-patient-with-severe-hEFFqkhS1C
SP - 436
EP - 440
VL - 113
IS - 3
DP - DeepDyve
ER -