TY - JOUR AU1 - Schulz, André AU2 - Germann, Anja AU3 - Heinz, Werner R. AU4 - Engelhard, Melanie AU5 - Menz, Helge AU6 - Rickmann, Annekatrin AU7 - Meiser, Ina AU8 - Wien, Sascha AU9 - Wagner, Sylvia AU1 - Januschowski, Kai AU1 - Szurman, Peter AB - INTRODUCTIONThe native vitreous is a hydrophilic matrix that plays a major role in ocular embryogenesis, maintenance of homeostasis in the eye and multiple interactions with neighbouring structures (Sebag, 2014). The treatment of vitreoretinal pathologies such as retinal detachments requires the removal of the vitreous (vitrectomy) and the stabilization of the retina with an endotamponade. As tamponading agents, silicone oils (Azen et al., 1998; Chen et al., 2021), perfluorinated alkanes (e.g. C8F18 and F6H8) (Barthelmes & Chandra, 2015; Kirchhof et al., 2002) and gases (e.g. SF6, air) (Cheng et al., 2020; Kim et al., 2008) are currently in clinical use. However, compared with the native human vitreous, these endotamponades deviate in hydrophilicity, refractive index and density, potentially leading to various complications such as emulsification, blurred vision, increased intraocular pressure, prolonged inflammation, cataract formation or the need for additional surgery (in cases where the tamponade must be removed). In patients with multiple retinal breaks contralateral to each other, proliferative vitreoretinopathy or persistent hypotension, the hydrophobic character of these endotamponades is a significant disadvantage (Kleinberg et al., 2011; Mondelo‐García et al., 2021).Endotamponades are implanted into the human body as single‐use, compensation/replacement medical devices via intervention by healthcare professionals and are covered by the medical device regulation (MDR) EU 745/2017 (article 2). TI - Translation of hyaluronic acid–based vitreous substitutes towards current regulations for medical devices JF - Acta Ophthalmologica DO - 10.1111/aos.15301 DA - 2023-06-01 UR - https://www.deepdyve.com/lp/wiley/translation-of-hyaluronic-acid-based-vitreous-substitutes-towards-hB9fjsqaPc SP - 422 EP - 432 VL - 101 IS - 4 DP - DeepDyve ER -