TY - JOUR
AU1 - Schulz, André
AU2 - Germann, Anja
AU3 - Heinz, Werner R.
AU4 - Engelhard, Melanie
AU5 - Menz, Helge
AU6 - Rickmann, Annekatrin
AU7 - Meiser, Ina
AU8 - Wien, Sascha
AU9 - Wagner, Sylvia
AU1 - Januschowski, Kai
AU1 - Szurman, Peter
AB - INTRODUCTIONThe native vitreous is a hydrophilic matrix that plays a major role in ocular embryogenesis, maintenance of homeostasis in the eye and multiple interactions with neighbouring structures (Sebag, 2014). The treatment of vitreoretinal pathologies such as retinal detachments requires the removal of the vitreous (vitrectomy) and the stabilization of the retina with an endotamponade. As tamponading agents, silicone oils (Azen et al., 1998; Chen et al., 2021), perfluorinated alkanes (e.g. C8F18 and F6H8) (Barthelmes & Chandra, 2015; Kirchhof et al., 2002) and gases (e.g. SF6, air) (Cheng et al., 2020; Kim et al., 2008) are currently in clinical use. However, compared with the native human vitreous, these endotamponades deviate in hydrophilicity, refractive index and density, potentially leading to various complications such as emulsification, blurred vision, increased intraocular pressure, prolonged inflammation, cataract formation or the need for additional surgery (in cases where the tamponade must be removed). In patients with multiple retinal breaks contralateral to each other, proliferative vitreoretinopathy or persistent hypotension, the hydrophobic character of these endotamponades is a significant disadvantage (Kleinberg et al., 2011; Mondelo‐García et al., 2021).Endotamponades are implanted into the human body as single‐use, compensation/replacement medical devices via intervention by healthcare professionals and are covered by the medical device regulation (MDR) EU 745/2017 (article 2). 
TI - Translation of hyaluronic acid–based vitreous substitutes towards current regulations for medical devices
JF - Acta Ophthalmologica
DO - 10.1111/aos.15301
DA - 2023-06-01
UR - https://www.deepdyve.com/lp/wiley/translation-of-hyaluronic-acid-based-vitreous-substitutes-towards-hB9fjsqaPc
SP - 422
EP - 432
VL - 101
IS - 4
DP - DeepDyve
ER -