TY - JOUR
AB - A novel series of N-(3-(6-substituted-aminopyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting TrkA receptor tyrosine kinase was identified. SAR study of the series allowed us to design and synthesize compounds possessing inhibitory activity of TrkA kinase enzyme in the low nanomolar range with low residual activity against c-Met and with no significant activity against VEGFR2.
TI - Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors
DO - 10.1155/2012/412614
DA - 2014-01-19
UR - https://www.deepdyve.com/lp/wiley/identification-of-a-novel-series-of-potent-trka-receptor-tyrosine-h5EtYAL7kL
DP - DeepDyve
ER -