TY - JOUR
AU - Langford, R.M.
AB - Journal of Analytical Toxicology, Vol. 23, March/April 1999 I Leuerto theEditor A Safer Method for the Measurement of Plasma Thiocyanate To the Editor: The low levels of thiocyanate (SCN) normally present in body fluids increase with chronic exposure to cyanide. Thus, the measurement of plasma SCN is important in studies of cigarette smokers (1), for monitoring patients during lengthy infusions with sodium nitroprusside (SNP) (2), and in surveys of populations consuming cyanogenic plant foods (3). The most sensitive colorimetric procedures for measuring SCN (and also cyanide) employ various modifications of the K6nig synthesis of pyridine dyestuffs. SCN is first converted to cyanogen halide with bromine or chloramine T. On addition of a mixture of pyridine and a primary amine, a colored product is obtained. However, pyridine has a most unpleasant odor and is potentially toxic, and the primary amines may be carcinogenic. As a result, they have been replaced by the less noxious isonicotinic and barbituric acids, respectively (4). More recently, 1,3-dimethylbarbituric acid has been used in place of barbituric acid because of the more rapid reaction and formation of an end-product which is more highly colored (5,6). Lundquist et al. (7) have employed these two reagents for the 
TI - A Safer Method for the Measurement of Plasma Thiocyanate
JO - Journal of Analytical Toxicology
DO - 10.1093/jat/23.2.134
DA - 1999-03-01
UR - https://www.deepdyve.com/lp/oxford-university-press/a-safer-method-for-the-measurement-of-plasma-thiocyanate-gvl2nORsUb
SP - 134
EP - 136
VL - 23
IS - 2
DP - DeepDyve
ER -