TY - JOUR
AU - LESKOWITZ, SIDNEY
AB - August 7, 1965 vaL. zo7 596 NATURE ROLE OF THE CARRIER IN DEVELOPMENT OF DELA YEO SENSITIVITY TO THE AZOPHENYL-ARSONATE GROUP By DR. VALERIE E. JONES* and DR. SIDNEY LESKOWITZ Medical Service, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston UINEA-PIGS immunized with hapten-protein con­ that was universally effective in producing hapten­ G jugates produce antibody which is hapten-specific, specific delayed sensitivity. Again, there was a suggestion but exhibit a delayed hypersensitivity which is directed of some contribution by the tyrosine group to the azo­ largely toward the protein carrier • When, however, phonylarsonate reactivity in the markedly greater arsanilic acid was used as a hapten and polytyrosine as the reactions produced with ars-insulin. The copolymer of carrier, a delayed hypersensitivity resulted which was glutamic acid, alanine and tyrosine was also an effective hapten-specific • Since this represented the only clear-cut carrier for production of delayed sensitivity with all case of hapten-directed delayed sensitivity, it became of animals showing reactivity to ars-insulin. In confirma­ interest to assess the relative importance of the hapten tion of studies by Benacerraf et al.•, the polymer synthe­ and the carrier in its production. sized from the D-isomers 
TI - Role of the Carrier in Development of Delayed Sensitivity to the Azophenyl-Arsonate Group
JF - Nature
DO - 10.1038/207596a0
DA - 1965-08-01
UR - https://www.deepdyve.com/lp/springer-journals/role-of-the-carrier-in-development-of-delayed-sensitivity-to-the-gp3LIcJsGi
SP - 596
EP - 597
VL - 207
IS - 4997
DP - DeepDyve
ER -