TY - JOUR
AU - Bhattacharya, Pratip
AB - Magn Reson Mater Phy (2009) 22:111–121 DOI 10.1007/s10334-008-0155-x RESEARCH ARTICLE PASADENA hyperpolarization of C biomolecules: equipment design and installation Jan-Bernd Hövener · Eduard Y. Chekmenev · Kent C. Harris · William H. Perman · Larry W. Robertson · Brian D. Ross · Pratip Bhattacharya Received: 28 November 2007 / Revised: 24 October 2008 / Accepted: 5 November 2008 / Published online: 6 December 2008 © ESMRMB 2008 Abstract Results Together with an available parahydrogen generator, Object The PASADENA method has achieved hyperpolari- the polarizer, which can be operated by a single investi- zation of 16–20% (exceeding 40,000-fold signal enhance- gator, completes one cycle of hyperpolarization each 52 s. ment at 4.7 T), in liquid samples of biological molecules Evidence of efficacy is presented. In contrast to competing, relevant to in vivo MRI and MRS. However, there exists commercially available devices for dynamic nuclear pola- no commercial apparatus to perform this experiment conve- rization which characteristically require 90 min per cycle, niently and reproducibly on the routine basis necessary for PASADENA provides a low-cost alternative for high translation of PASADENA to questions of biomedical impor- throughput. tance. The present paper describes equipment designed for Conclusions This equipment is suited to 
TI - PASADENA hyperpolarization of 13C biomolecules: equipment design and installation
JO - Magnetic Resonance Materials in Physics, Biology and Medicine
DO - 10.1007/s10334-008-0155-x
DA - 2008-12-06
UR - https://www.deepdyve.com/lp/springer-journals/pasadena-hyperpolarization-of-13c-biomolecules-equipment-design-and-gowKLIxqw0
SP - 111
EP - 121
VL - 22
IS - 2
DP - DeepDyve
ER -