TY - JOUR
AU - Havell, Edward A.
AB - Mice acquired an enhanced capacity for the production oftumor necrosis factor (TNF) and the interferons (IFN)-α, and -β shortly after intravenous injection of viable Listeria monocytogenes. By the end of the first day of a sublethal infection, mice were primed to produce 100-1000 times more endotoxin-induced serum TNF than is produced by normal mice. Acquisition of the augmented capacity for TNF production was due to L. monocytogenes-induced IFN-γ. IFN-γ also primed infected mice for IFN-α/β production. However, in addition to IFN-γ, other L. monocytogenes- induced mechanisms endowed the host with an enhanced potential for the production of IFN-α/β. Antibody-mediated depletion of various cell types in vivo revealed that CD8+ cells and NK cells are required for the production of L. monocytogenes-induced IFN-γ during the first day of listeriosis.
TI - Listeria monocytogenes-Induced Interferon-v Primes the Host for Production of Tumor Necrosis Factor and Interferon-α/β
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/167.6.1364
DA - 1993-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/listeria-monocytogenes-induced-interferon-v-primes-the-host-for-gnxj5em0oh
SP - 1364
EP - 1371
VL - 167
IS - 6
DP - DeepDyve
ER -