TY - JOUR
AU - Hall, Michelle
AB - INTRODUCTIONOsteoarthritis (OA) is a major cause of pain and disability (1), typically affecting the knees, hips, hands, and feet (2). Clinical guidelines recommend nonpharmacologic and pharmacologic approaches prior to surgical intervention (3–5). However, the mechanism(s) by which many nonsurgical interventions improve pain and physical function remains unclear. With this limited understanding, it is perhaps unsurprising that nonsurgical interventions have, at best, modest clinical benefits and that increasing volumes of patients opt to undergo joint arthroplasty (6). Understanding the mechanisms that mediate intervention effects can result in more targeted delivery and implementation, in addition to providing the impetus for new treatments or treatment combinations.SIGNIFICANCE & INNOVATIONSIdentifying mediators of nonsurgical interventions for osteoarthritis (OA) will help guide their optimization and the development of new interventions.No studies have evaluated putative mediators of nonsurgical interventions on pain or physical function for osteoarthritic joints, other than the knee.Reduced inflammation, reduced body weight, increased knee extensor muscle strength, and increased self‐efficacy may mediate beneficial effects of nonsurgical interventions on knee OA pain and/or physical dysfunction.One method for understanding how interventions influence outcomes is mediation analysis of a randomized controlled trial (RCT). Mediation analyses can estimate the effect of an intervention on an outcome through an 
TI - How Do Nonsurgical Interventions Improve Pain and Physical Function in People With Osteoarthritis? A Scoping Review of Mediation Analysis Studies
JF - Arthritis Care & Research
DO - 10.1002/acr.24983
DA - 2023-03-01
UR - https://www.deepdyve.com/lp/wiley/how-do-nonsurgical-interventions-improve-pain-and-physical-function-in-gifgJu7Mrj
SP - 467
EP - 481
VL - 75
IS - 3
DP - DeepDyve
ER -