TY - JOUR
AU - KISHIMOTO, S
AB - SUMMARY The role of tumour necrosis factor-alpha (TNF-α) in the development of autoimmune pulmonary inflammation has been investigated in lupus-prone mice. An increase in TNF-α mRNA level from whole lung preparation of lupus-prone mice was evident, from 3 weeks to 12 weeks during growing process, as shown by Northern blot analysis, but not in control mice. Furthermore, it is also found that the major source of this increase in TNF-α mRNA was attributed to infiltrating mononuclear cells found within the lung. Treatment of lupus-prone mice with rabbit anti-mouse TNF-α IgG prevented the development of pulmonary inflammation lesions such as lung fibrosis and alveolitis. These results suggest that an increased TNF-α production by infiltrating mononuclear cells in the lungs of lupus-prone mice may play a role in the development of autoimmune pulmonary inflammation and in significant changes of cytokines and the immune responses in pulmonary inflammation lesions of lupus-prone mice. tumour necrosis factor, lupus, pulmonary inflammation, transcription, lymphoid REFERENCES Alexander , E.L. , Moyer , C., Travlos , G.S., Roth , J.B. & Murphy , E.D. ( 1985 ) Two histopathological types of inflammatory vascular disease in MRL/Mp autoimmune mice. Model for human vasculitis in connective tissue disease . Arthritis Rheum . 28 , 1146 . Google Scholar Crossref Search ADS PubMed WorldCat Andrews , B.S. , Eisenberg , R.A., Theofilopoulos , A.N., Izui , S., Wilson , C.B., McConahey , P.J., Murphy , E.D., Roths , J.B. & Dixon , F.J. ( 1978 ) Spontaneous murine lupus-like syndromes . J. exp. Med . 148 , 1198 . Google Scholar Crossref Search ADS PubMed WorldCat Berden , J.H.M. , Hang , L.M., McConahey , P.J. & Dixon , F.J. ( 1983 ) Analysis of vascular lesions in murine SLE. I. Association with serologic abnormalities , J. Immunol . 130 , 1699 . Google Scholar PubMed OpenURL Placeholder Text WorldCat Beutler B. & Cerami , A. ( 1987 ) Cachectin: more than a tumor necrosis factor . N. Engl. J. Med . 316 , 379 . Google Scholar PubMed OpenURL Placeholder Text WorldCat Beutler , B. & Cerami , A. ( 1938 ) Tumour necrosis, cachexia, shock and inflammation: a common mediator . Annu. Rev. Biochem , 57 , 505 . Google Scholar Crossref Search ADS WorldCat Chomcyzski , P. & Sacchi , N. ( 1987 ) Single-step methods of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extrac tion . Anal. Biochem , 162 , 156 . Google Scholar Crossref Search ADS PubMed WorldCat Deguchi , Y. , Negoro , S., Hara , H. & Kishimoto , S. ( 1987 ) Protooncogene expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus as an indicator of the disease activity . Clin. Immunol. Immunopathol . 45 , 424 . Google Scholar Crossref Search ADS PubMed WorldCat Dixon , F.J. , Theofilopoulos , A.N., Izui , S. & McConahey , P.J. ( 1980 ) Murine SLE-etiology and pathogenesis . In Immunology 80 (ed. by M. Fougereau & J. Dausset) p. 959 . Academic Press , London . Google Scholar Google Preview OpenURL Placeholder Text WorldCat COPAC Grau , G.E. , Kindler , V., Piguet , P.F., Lambert , P.H. & Vassalli , P. ( 1988 ) Prevention of experimental cerebral malaria by anticytokine antibodies, Interleukin 3 and granulocyte macrophage colony-stimulating factors are intermediates in increased tumor necrosis factor production and macrophage accumulation . J. exp, Med . 168 , 1499 . Google Scholar Crossref Search ADS WorldCat Marzluff , W.F. & Huang , R.C.C. ( 1984 ) In vitro transcription . In Transcription and Translation . (ed. by R. C. C. Huang) p. 89 . IRL Press , Oxford . Google Scholar Google Preview OpenURL Placeholder Text WorldCat COPAC Reed , J.C , Tsujimoto , Y. & Alpers , J.G. ( 1987 ) Expression of bcl-2 protooncogene during normal human lymphocyte proliferation . Science . 236 , 1295 . Google Scholar Crossref Search ADS PubMed WorldCat Ruff , M.R. & Gifford , G.E. ( 1981 ) Tumor necrosis factor . Lymphokines . 2 , 235 . Google Scholar OpenURL Placeholder Text WorldCat Tan , E.M. , Cohen , A.S., Fries , J.F., Masi , AT., McShane , D.J., Rothfield , N.F., Schaller , J.G., Talal , N. & Winchester , RJ. ( 1982 ) The 1982 revised criteria for the classification of systemic lupus erythematosus . Arthritis Rheum , 25 , 1271 . Google Scholar Crossref Search ADS PubMed WorldCat Tracy , K.J. , Wey , H. & Manogue , K.R., Fong , Y., Hesse , D.G., Nguyen , H.T., Kus , G.C., Beutler , B., Cotran , R.S., Cerami , A. & Lowry , S.F. ( 1988 ) Cachectin/TNF induces cachexia/shock and inflammation . J. exp. Med . 167 , 1211 . Google Scholar Crossref Search ADS PubMed WorldCat This content is only available as a PDF. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Tumour necrosis factor/cachectin plays a key role in autoimmune pulmonary inflammation in lupus-prone mice
JO - Clinical & Experimental Immunology
DO - 10.1111/j.1365-2249.1991.tb05737.x
DA - 2008-06-28
UR - https://www.deepdyve.com/lp/oxford-university-press/tumour-necrosis-factor-cachectin-plays-a-key-role-in-autoimmune-gWB06nrK82
SP - 392
EP - 395
VL - 85
IS - 3
DP - DeepDyve
ER -