TY - JOUR
AU1 - Zhang, Xiu-Hang
AU2 - Cui, Chang-Lei
AU3 - Zhu, Hao-Yue
AU4 - Wang, Jian
AU5 - Xue, Yan
AU6 - Zhang, Nan
AU7 - Sun, Zhan-Ao
AU8 - Gao, Xin-Xin
AU9 - Zhou, Xin
AU1 - Yu, Jia-Ao
AU1 - Chen, Xin-Xin
AB - The aim of the study was to investigate the effects of the rhGM-CSF gel on third-degree frostbite wounds. Sixty-two patients who had suffered third-degree frostbite on their hand or foot (91 wounds in total) were selected using a convenience sampling method and randomly allocated to two groups: the rhGM-CSF group(31patients,45 frostbite wounds) received the rhGM-CSF gel when wound dressing change daily; however, the control group (31patients, 46 frostbite wounds) received aloe glue. The wound healing time, the score of inflammation about the wound and the positive bacterial culture of wound secretions were used to measure outcomes, respectively. Data were analyzed using SPSS (25.0), Student’s t test or Mann–Whitney U test and chi-square test or Fisher exact test were selected, as appropriate. The healing time of the rhGM-CSF group was (12.2 ± 5.0) days, which was significantly shorter than that of the control group (15.5 ± 4.7) days (P < .0001). The rhGM-CSF group’s wound inflammation scores on the 7th and 14th day of treatment were (0.96 ± 0.21) and (1.88 ± 0.29), respectively, which were better than those of the control group (1.12 ± 0.24) and (1.38 ± 0.15) (both P < .0001). The positive bacterial culture of wound secretions in the rhGM-CSF group was also better than that in the control group on the 3rd, 7th, and 14th day after treatment (P = .027, .004, .030, respectively). According to the results, using rhGM-CSF gel considerably increases the speed of frostbite wounds healing, and have an effect on protecting third-degree frostbite wounds regarding the positive effects.Trial Registration: This trial was registered in the Chinese Clinical Trial Register, ChiCTR1900021299.
TI - The Effects of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor Gel on Third-Degree Frostbite Wounds in Northeastern China: A Randomized Controlled Trial
JF - Journal of Burn Care & Research
DO - 10.1093/jbcr/iraa019
DA - 2020-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-effects-of-recombinant-human-granulocyte-macrophage-colony-gTe1ZB2pz4
SP - 715
EP - 722
VL - 44
IS - 3
DP - DeepDyve
ER -