TY - JOUR
AU - O'Brien, Rebecca L.
AB - Although the TNF receptor family member CD27 has been known for some time, its functional role as a coreceptor on T and B cells remains poorly understood. Recent reports have shown that CD27 and its ligand CD70 play a critical role in the development and function of γδ T cells in mice. In this issue of the European Journal of Immunology, a study now extends these findings to the Vγ9Vδ2+ subset of human γδ T cells. This subset, whose responses are readily elicited by phosphoantigens, plays an important role in anti‐tumor immune responses. This study shows that most Vγ9Vδ2+ cells express CD27, and signaling via the CD27‐CD70 axis is needed for their survival, proliferation and cytokine secretion. Moreover, CD27 functions as a coreceptor, which promotes, in conjunction with TCR‐mediated signals, expansion of Th1‐biased Vγ9Vδ2+ cells. This new information underscores the significance of CD27 in γδ T‐cell functional differentiation, and is likely to facilitate the development of γδ T‐cell‐based clinical immunotherapy.
TI - γδ T cells develop, respond and survive – with a little help from CD27
JO - European Journal of Immunology
DO - 10.1002/eji.201041270
DA - 2011-01-01
UR - https://www.deepdyve.com/lp/wiley/t-cells-develop-respond-and-survive-with-a-little-help-from-cd27-gTQh0KfWge
SP - 26
EP - 28
VL - 41
IS - 1
DP - DeepDyve
ER -