TY - JOUR
AU1 - Ye, Yumei
AU2 - Qian, Jinqiao
AU3 - Castillo, Alexander
AU4 - Perez-Polo, Jose
AU5 - Birnbaum, Yochai
AB - AL, dose dependently limited myocardial IS in mice with type-2 diabetes mellitus. At doses shown to limit IS in non-diabetic animals, VA failed to reduce IS in Db/Db mice. However, at higher dose (16 mg/kg/d), VA reduced IS. Both drugs reduced the expression of AT1R and increased myocardial levels of the longevity genes Sirt1 and PGC-1α along with increased Akt and eNOS phosphorylation.
TI - Aliskiren and Valsartan Reduce Myocardial AT1 Receptor Expression and Limit Myocardial Infarct Size in Diabetic Mice
JF - Cardiovascular Drugs and Therapy
DO - 10.1007/s10557-011-6339-z
DA - 2011-10-11
UR - https://www.deepdyve.com/lp/springer-journals/aliskiren-and-valsartan-reduce-myocardial-at1-receptor-expression-and-gLjjvgbo0r
SP - 505
EP - 515
VL - 25
IS - 6
DP - DeepDyve
ER -