TY - JOUR
AU1 - Strong, Dawn
AU2 - Hébert, Diane
AB - A 5-year-old girl with a kidney transplant developed post-transplant Epstein-Barr virus-induced lymphoproliferative disease. She was treated with acyclovir, α-interferon, and gamma globulin. A transplant nephrectomy was performed on day 4 due to acute rejection and she was started on hemodialysis. The acyclovir dose was decreased at this time. However, 6 days following the start of acyclovir she developed progressively worsening neurological symptoms resulting in a coma on day 8. Fourteen days after acyclovir was begun pre- and post-dose serum concentrations were 7.02 μM and 182.5 μM, respectively. Acyclovir was then discontinued and 2 days later the child’s neurological status began to improve. We conclude that acyclovir in children with end-stage renal failure may lead to severe and reversible neurotoxicity, despite acyclovir dosage adjustment based on renal impairment.
TI - Acute acyclovir neurotoxicity in a hemodialyzed child
JF - Pediatric Nephrology
DO - 10.1007/s004670050379
DA - 2014-03-01
UR - https://www.deepdyve.com/lp/springer-journals/acute-acyclovir-neurotoxicity-in-a-hemodialyzed-child-gGGEkfax5J
SP - 741
EP - 743
VL - 11
IS - 6
DP - DeepDyve
ER -