TY - JOUR
AU - FISHER, DELBERT, A.
AB - Abstract Serum LATS content and suppressibility of 20-min thyroid 131I uptake have been examined at frequent intervals in 15 patients with hyperthyroidism due to Graves' disease during treatment with antithyroid drugs. LATS was measured in precisely 10-fold concentrates of immunoglobulin G prepared by salt fractionation. The method had an average recovery of 95% and was sensitive to 0.13 MRC mU/ml. After 4.5 to 7.5 months of treatment, thyroid 131I uptake became suppressible by triiodothyronine in 4 patients; in only 2 of these was LATS undetectable. Among 11 patients in whom 131I uptake was not suppressible after 4.5 to 12 months of treatment, LATS was undetectable in 7. Serum TSH was also measured, and its reappearance in normal or supranormal concentrations, as the patients became euthyroid or hypothyroid, was not associated with normalization of suppression of 131I uptake by triiodothyronine. These data lend no support to the hypothesis that nonsuppressibility in Graves' disease is due to circulating LATS and that return of suppressibility is due to a fall in LATS and reappearance of TSH in serum. The data raise the possibility that the cause of nonsuppressibility may be an intrinsic thyroid abnormality. This content is only available as a PDF. Author notes This work was supported by grants from the John A. Hartford Foundation, Inc., and from USPHS (AM-10187). Copyright © 1970 by The Endocrine Society
TI - Dissociation of Serum LATS Content and Thyroid Suppressibility During Treatment of Hyperthyroidism
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jcem-30-4-524
DA - 1970-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/dissociation-of-serum-lats-content-and-thyroid-suppressibility-during-gAxT4CWWqR
SP - 524
EP - 528
VL - 30
IS - 4
DP - DeepDyve
ER -