TY - JOUR AU - Carpéné, C. AB - © Birkhäuser Verlag, Basel, 2003 Inflamm. res. 52, Supplement 1 (2003) S55– S56 1023-3830/03/01S55-02 Inflammation Research 5. Histamines metabolism and polyamines Histamine antilipolytic action in rat adipocytes: comparison with the effect of tyramine G. Meissonnier, A. Heniquez, V. Visentin, D. Prévot and C. Carpéné U317 INSERM, IFR 31, Bat. L3, CHU Rangueil, 31403 Toulouse, France, Fax: ++ 33 5 61 33 17 21, e-mail: carpene@toulouse.inserm.fr Introduction almost complete blockade at 1 mM while, at the same con- centration, histamine was partially, but significantly, The termination of the multiple actions of histamine is antilipolytic (Fig. 1). Benzylamine, a synthetic substrate of dependent on the inactivation of this signal molecule by SSAO, and methylamine, the proposed endogenous substrate amine oxidase or histamine-N-methyl-transferase in the cen- of SSAO, were also partially antilipolytic (Fig. 1). In order to tral nervous system and in peripheral tissues. We have recent- verify whether these antilipolytic effects were dependent on ly reported that the oxidation of histamine induces a stimula- amine oxidation, similar experiments were conducted on ani- tion of glucose uptake in rat adipocytes [1]. This histamine- mals previously treated by i. p. administration with the MAO- stimulated glucose transport is inhibited by inhibitors of inhibitor TI - 5. Histamines metabolism and polyaminesHistamine antilipolytic action in rat adipocytes: comparison with the effect of tyramine JF - Inflammation Research DO - 10.1007/s000110300053 DA - 2003-04-01 UR - https://www.deepdyve.com/lp/springer-journals/5-histamines-metabolism-and-polyamineshistamine-antilipolytic-action-g8wbC0xdRB SP - s55 EP - s56 VL - 52 IS - 1 DP - DeepDyve ER -