TY - JOUR
AU - Donoso, Larry A.
AB - Abstract • Monoclonal antibody (MAb) 8-1H defines a highly conserved ocular melanoma-associated antigen. Based on a potential binding site of MAb8-1, we identified, molecularly cloned, and sequenced the gene, encoding this melanoma-associated antigen from a uveal melanoma copy DNA library. Nucleotide sequence analysis of the melanoma-associated antigen revealed characteristics of a membrane-bound protein of 238 amino acids (approximately 25 kd) with four transmembrane domains. The sequence of the ocular melanoma-associated antigen is identical to the sequence of a recently reported cutaneous melanomaassociated antigen, substantiating our previous studies regarding common antigens between ocular and cutaneous melanoma. In addition, the melanomaassociated antigen shares sequence homology with a number of transmembrane proteins that appear to be involved in growth regulation. 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TI - An Ocular Melanoma-Associated Antigen: Molecular Characterization
JF - Archives of Ophthalmology
DO - 10.1001/archopht.1992.01080150097036
DA - 1992-03-01
UR - https://www.deepdyve.com/lp/american-medical-association/an-ocular-melanoma-associated-antigen-molecular-characterization-g5E0ebbMC4
SP - 399
EP - 404
VL - 110
IS - 3
DP - DeepDyve
ER -