TY - JOUR
AU1 - YOKOTA,, M.
AU2 - SAITO,, F.
AU3 - IZAWA,, H.
AU4 - MATSUNAMI,, T.
AU5 - YOSHIDA,, J.
AU6 - INAGAKI,, H.
AU7 - SOTOBATA,, I.
AB - Abstract Twenty-four patients with chronic stable exertional angina pectoris were randomized in a double-blind, placebo-controlled, crossover trial to assess the efficacy and durability of a newly developed, sustained-release formulation of nifedipine (nifedipine CC) in a single 40-mg oral dose. Symptom-limited graded treadmill exercise tests were performed just before, and at 4, 7, and 24 h after a single administration of the drug or the placebo was given. Exercise tolerance at 4, 7, and 24 h after the drug were compared with the corresponding placebo values. Data could be analysed for 19 patients. Maximal exercise time, time to the onset of angina, and time to 1 mm ST segment depression were significantly greater at 4, 7, and 24 h after nifedipine CC than at baseline or with the corresponding placebo. The average maximal exercise time was significantly increased by 72, 76, and 37 s at 4, 7, and 24 h. Rate-pressure product at rest and at peak exercise showed significant changes only at 24 h compared with placebo (both P<0.05). The maximal increase in exercise tolerance was most marked at 7 h after nifedipine CC, at which time plasma drug concentration was 99.4 ± 14. 0 ng. ml−1. Thus, in patients with chronic stable exertional angina pectoris, nifedipine CC showed a prolonged improvement in exercise tolerance up to 24 h after a single oral administration. Effort angina, nifedipine, sustained-release formulation, exercise tolerance, modified Brace's protocol This content is only available as a PDF. © 1994 The European Society of Cardiology
TI - Duration and extent of antianginal effects of a sustained-release formulation of nifedipine in angina
JF - European Heart Journal
DO - 10.1093/oxfordjournals.eurheartj.a060617
DA - 1994-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/duration-and-extent-of-antianginal-effects-of-a-sustained-release-fpybsBvw2F
SP - 965
EP - 970
VL - 15
IS - 7
DP - DeepDyve
ER -