TY - JOUR
AU - MacAulay, Calum E.
AB - Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. We describe a simple handheld device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions. Blue excitation light (400 to 460 nm ) is employed to excite green-red fluorescence from fluorophores in the oral tissues. Tissue fluorescence is viewed directly along an optical axis collinear with the axis of excitation to reduce inter- and intraoperator variability. This robust, field-of-view device enables the direct visualization of fluorescence in the context of surrounding normal tissue. Results from a pilot study of 44 patients are presented. Using histology as the gold standard, the device achieves a sensitivity of 98&percent; and specificity of 100&percent; when discriminating normal mucosa from severe dysplasia/carcinoma in situ (CIS) or invasive carcinoma. We envisage this device as a suitable adjunct for oral cancer screening, biopsy guidance, and margin delineation.
TI - Simple device for the direct visualization of oral-cavity tissue fluorescence
JF - Journal of Biomedical Optics
DO - 10.1117/1.2193157
DA - 2006-03-01
UR - https://www.deepdyve.com/lp/spie/simple-device-for-the-direct-visualization-of-oral-cavity-tissue-fgPC5VPvho
SP - 024006
EP - 024006-7
VL - 11
IS - 2
DP - DeepDyve
ER -